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SMILES: CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1cnc2c(N)nccn12

InChI Key: InChIKey=SJEXQETYPPZBHL-NSHDSACASA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 474023   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM474023
PNG
(6-(8-Aminoimidazo[1,2-a]pyrazin-3-yl)-2-[(1S)-1-cy...)
Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1cnc2c(N)nccn12 |r|
Show InChI InChI=1S/C20H22N6O3S/c1-11(12-3-4-12)26-10-14-7-13(8-16(17(14)20(26)27)30(28,29)22-2)15-9-24-19-18(21)23-5-6-25(15)19/h5-9,11-12,22H,3-4,10H2,1-2H3,(H2,21,23)/t11-/m0/s1
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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...

US Patent US10858355 (2020)

More data for this
Ligand-Target Pair