BDBM474536 US10882844, Example 1004

SMILES: Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3CCCC[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2oc(nc2c1)C1CCNCC1

InChI Key: InChIKey=DIRZDIHMAJEZQX-DHUJRADRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 474536   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death 1 ligand/protein 1 (Homo sapiens-Homo sapiens (Human))	BDBM474536 (US10882844, Example 1004) Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3CCCC[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2oc(nc2c1)C1CCNCC1 |r| Show InChI InChI=1S/C40H40ClN5O5/c1-25-30(5-4-6-32(25)29-8-9-36-34(17-29)45-39(51-36)28-10-12-43-13-11-28)24-50-38-18-37(49-23-27-15-26(19-42)20-44-21-27)31(16-33(38)41)22-46-14-3-2-7-35(46)40(47)48/h4-6,8-9,15-18,20-21,28,35,43H,2-3,7,10-14,22-24H2,1H3,(H,47,48)/t35-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...				US Patent US10882844 (2021)
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