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SMILES: CCS(=O)(=O)c1cc2nc([nH]c2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O

InChI Key: InChIKey=WUXRPHJBNTVNEN-UHFFFAOYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 475543   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Egl nine homolog 1 [181-417]


(Homo sapiens (Human))		BDBM475543
PNG
(1-(5-Ethylsulfonyl-6-trifluoromethoxy-1H-benzoimid...)
Show SMILES CCS(=O)(=O)c1cc2nc([nH]c2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H11F3N4O5S/c1-2-27(24,25)11-4-9-8(3-10(11)26-14(15,16)17)19-13(20-9)21-6-7(5-18-21)12(22)23/h3-6H,2H2,1H3,(H,19,20)(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25.1n/an/an/an/an/an/a


TBA

Assay Description
The PHD2 181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypep...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2V69PHV
More data for this
Ligand-Target Pair
Egl nine homolog 1 [181-417]


(Homo sapiens (Human))		BDBM475543
PNG
(1-(5-Ethylsulfonyl-6-trifluoromethoxy-1H-benzoimid...)
Show SMILES CCS(=O)(=O)c1cc2nc([nH]c2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H11F3N4O5S/c1-2-27(24,25)11-4-9-8(3-10(11)26-14(15,16)17)19-13(20-9)21-6-7(5-18-21)12(22)23/h3-6H,2H2,1H3,(H,19,20)(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...

US Patent US10851083 (2020)


BindingDB Entry DOI: 10.7270/Q25B05K9
More data for this
Ligand-Target Pair