null

SMILES: CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(F)c2)C1

InChI Key: InChIKey=SZSUODVWKTUPAX-ONEGZZNKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475629 (US10851102, Example 22 | US11339160, Ex No. 22) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(F)c2)C1 Show InChI InChI=1S/C23H25FN4O3/c1-26(2)7-3-4-23(30)27-11-16(12-27)14-31-22-9-18(13-28-15-25-10-20(22)28)17-5-6-21(29)19(24)8-17/h3-6,8-10,13,15-16,29H,7,11-12,14H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent									US Patent US10851102 (2020) BindingDB Entry DOI: 10.7270/Q2N87DV3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475629 (US10851102, Example 22 | US11339160, Ex No. 22) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(F)c2)C1 Show InChI InChI=1S/C23H25FN4O3/c1-26(2)7-3-4-23(30)27-11-16(12-27)14-31-22-9-18(13-28-15-25-10-20(22)28)17-5-6-21(29)19(24)8-17/h3-6,8-10,13,15-16,29H,7,11-12,14H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM475629 (US10851102, Example 22 | US11339160, Ex No. 22) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(F)c2)C1 Show InChI InChI=1S/C23H25FN4O3/c1-26(2)7-3-4-23(30)27-11-16(12-27)14-31-22-9-18(13-28-15-25-10-20(22)28)17-5-6-21(29)19(24)8-17/h3-6,8-10,13,15-16,29H,7,11-12,14H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM475629 (US10851102, Example 22 | US11339160, Ex No. 22) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(F)c2)C1 Show InChI InChI=1S/C23H25FN4O3/c1-26(2)7-3-4-23(30)27-11-16(12-27)14-31-22-9-18(13-28-15-25-10-20(22)28)17-5-6-21(29)19(24)8-17/h3-6,8-10,13,15-16,29H,7,11-12,14H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10851102 (2020) BindingDB Entry DOI: 10.7270/Q2N87DV3
					More data for this Ligand-Target Pair