BDBM480501 US10899756, Compound T

SMILES: COc1cc(Nc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)ccc1Cl

InChI Key: InChIKey=DQGJDYXZSRPPFW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 480501   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM480501 (US10899756, Compound T) Show SMILES COc1cc(Nc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)ccc1Cl Show InChI InChI=1S/C22H19ClN4O2/c1-13(28)27-8-7-20-17(12-27)22(16-9-14(11-24)3-6-19(16)26-20)25-15-4-5-18(23)21(10-15)29-2/h3-6,9-10H,7-8,12H2,1-2H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	425	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Columbia University in the City of New York US Patent					Assay Description A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...				US Patent US10899756 (2021)
					More data for this Ligand-Target Pair