null

SMILES: COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F

InChI Key: InChIKey=CKXLOJPROMTISJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482164   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482164 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C25H26ClFN6O3S/c1-32-10-8-15(9-11-32)33-13-18(22-24(28)29-14-30-25(22)33)17-4-3-5-20(23(17)27)31-37(34,35)16-6-7-21(36-2)19(26)12-16/h3-7,12-15,31H,8-11H2,1-2H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM482164 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C25H26ClFN6O3S/c1-32-10-8-15(9-11-32)33-13-18(22-24(28)29-14-30-25(22)33)17-4-3-5-20(23(17)27)31-37(34,35)16-6-7-21(36-2)19(26)12-16/h3-7,12-15,31H,8-11H2,1-2H3,(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description Compounds were 3-fold serially diluted in order to obtain from 3.333 to 0.000169 microM final concentration, then incubated for 60 minutes at room te...				US Patent US10918642 (2021) BindingDB Entry DOI: 10.7270/Q24Q7Z3P
					More data for this Ligand-Target Pair