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SMILES: Fc1ccc(cc1)-n1cc(-c2cccc(c2)C(F)(F)F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1

InChI Key: InChIKey=OIZBROMVFORZNF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486399   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM486399
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C(F)(F)F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H20F4N2O3S/c27-19-5-7-21(8-6-19)32-14-23(16-2-1-3-18(12-16)26(28,29)30)22-9-4-17(13-24(22)32)25(33)31-20-10-11-36(34,35)15-20/h1-9,12-14,20H,10-11,15H2,(H,31,33)
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PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...

US Patent US10947222 (2021)

More data for this
Ligand-Target Pair