BindingDB PrimarySearch

BDBM48804 3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-quinazolinone::3-(phenylmethyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one::3-benzyl-2-[(E)-2-(3-pyridyl)vinyl]quinazolin-4-one::3-benzyl-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one::MLS000709026::SMR000289793::cid_5738263

SMILES: O=c1n(Cc2ccccc2)c(\C=C\c2cccnc2)nc2ccccc12

InChI Key: InChIKey=GEKDQXSPTHHANP-OUKQBFOZSA-N

Data: 8 IC50 2 Kd 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 48804
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
eukaryotic translation initiation factor 4 gamma, 1 isoform 4 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	5.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2RN3686
					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	4.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
PCMD Curated by PubChem BioAssay					Assay Description Project Title: A screen for modulators of human Rad51, a key DNA repair protein Application Number: MH084119 Assay Submitter: Dr. Alex Mazin Submitte...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2VD6WW6
PCMD Curated by PubChem BioAssay					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
PCMD Curated by PubChem BioAssay					Assay Description Project Title: A screen for modulators of human Rad51, a key DNA repair protein Application Number: MH084119 Assay Submitter: Dr. Alex Mazin Submitte...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2QN6558
PCMD Curated by PubChem BioAssay					More data for this Ligand-Target Pair
putative hexokinase HKDC1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2W094D4
					More data for this Ligand-Target Pair
putative hexokinase HKDC1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q23F4N3R
					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of human RAD51				Bioorg Med Chem Lett 29: 2286-2289 (2019) Article DOI: 10.1016/j.bmcl.2019.06.024
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a
Drexel University College of Medicine Curated by ChEMBL					Assay Description Binding affinity to human RAD51 in absence of ATP by SPR method				J Med Chem 55: 3011-20 (2012) Article DOI: 10.1021/jm201173g BindingDB Entry DOI: 10.7270/Q2028SKG
Drexel University College of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a
Drexel University College of Medicine Curated by ChEMBL					Assay Description Inhibition of RAD1 (unknown origin) binding to ssDNA				Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7
Drexel University College of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a
Drexel University College of Medicine Curated by ChEMBL					Assay Description Binding affinity to RAD1 (unknown origin) by surface plasmon resonance method				Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7
Drexel University College of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University College of Medicine Curated by ChEMBL					Assay Description Inhibition of human RAD51-mediated DNA branch migration using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assay				J Med Chem 55: 3011-20 (2012) Article DOI: 10.1021/jm201173g BindingDB Entry DOI: 10.7270/Q2028SKG
Drexel University College of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University College of Medicine Curated by ChEMBL					Assay Description Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay				J Med Chem 55: 3011-20 (2012) Article DOI: 10.1021/jm201173g BindingDB Entry DOI: 10.7270/Q2028SKG
Drexel University College of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair