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BDBM4912 (3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::6-(4-Methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one::Indolin-2-one deriv. 4i

SMILES: COc1ccc(cc1)-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1

InChI Key: InChIKey=DPKWEIZIBQDTFF-STZFKDTASA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4912   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4912
PNG
((3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O2/c1-28-19-9-6-15(7-10-19)16-8-11-20-21(24(27)26-23(20)13-16)14-18-12-17-4-2-3-5-22(17)25-18/h6-14,25H,2-5H2,1H3,(H,26,27)/b21-14-
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n/an/a>2.00E+4n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 43: 2655-63 (2000)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2W66J0N
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4912
PNG
((3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O2/c1-28-19-9-6-15(7-10-19)16-8-11-20-21(24(27)26-23(20)13-16)14-18-12-17-4-2-3-5-22(17)25-18/h6-14,25H,2-5H2,1H3,(H,26,27)/b21-14-
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n/an/a>2.00E+4n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 43: 2655-63 (2000)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2W66J0N
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4912
PNG
((3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O2/c1-28-19-9-6-15(7-10-19)16-8-11-20-21(24(27)26-23(20)13-16)14-18-12-17-4-2-3-5-22(17)25-18/h6-14,25H,2-5H2,1H3,(H,26,27)/b21-14-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 43: 2655-63 (2000)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2W66J0N
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4912
PNG
((3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O2/c1-28-19-9-6-15(7-10-19)16-8-11-20-21(24(27)26-23(20)13-16)14-18-12-17-4-2-3-5-22(17)25-18/h6-14,25H,2-5H2,1H3,(H,26,27)/b21-14-
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n/an/a 9.40E+4n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 43: 2655-63 (2000)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2W66J0N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4912
PNG
((3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O2/c1-28-19-9-6-15(7-10-19)16-8-11-20-21(24(27)26-23(20)13-16)14-18-12-17-4-2-3-5-22(17)25-18/h6-14,25H,2-5H2,1H3,(H,26,27)/b21-14-
PDB
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KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
Article
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n/an/a>2.00E+4n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 43: 2655-63 (2000)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2W66J0N
More data for this
Ligand-Target Pair