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SMILES: CCc1c(C#N)c(SCc2ccc(cc2)N(C)S(C)(=O)=O)nc(N(C)CCNCCOC)c1C#N

InChI Key: InChIKey=ZKUJSFXRKGWKNH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 491497   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))		BDBM491497
PNG
(US10975056, Example 480)
Show SMILES CCc1c(C#N)c(SCc2ccc(cc2)N(C)S(C)(=O)=O)nc(N(C)CCNCCOC)c1C#N
Show InChI InChI=1S/C24H32N6O3S2/c1-6-20-21(15-25)23(29(2)13-11-27-12-14-33-4)28-24(22(20)16-26)34-17-18-7-9-19(10-8-18)30(3)35(5,31)32/h7-10,27H,6,11-14,17H2,1-5H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<320n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property Development Limited; Cancer Research Technology Ltd.

US Patent


Assay Description
Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...

US Patent US10975056 (2021)


BindingDB Entry DOI: 10.7270/Q2VM4GCT
More data for this
Ligand-Target Pair