BDBM50000925 7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one::7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one(BMY 20844)::BMY-20844::CHEMBL88583
SMILES: Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
InChI Key: InChIKey=ODCKPUDNMNCWMR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Purinergic receptor P2Y12 (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y12 (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 390 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3 | J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets | J Med Chem 34: 2906-16 (1991) BindingDB Entry DOI: 10.7270/Q20P0Z03 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50000925 (7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of cGMP hydrolysis by human platelet phosphodiesterase | J Med Chem 34: 2906-16 (1991) BindingDB Entry DOI: 10.7270/Q20P0Z03 | |||||||||||
More data for this Ligand-Target Pair |