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BDBM50001707 10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one::10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(oxymorphone)::10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(xymorphone)::10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one::CHEMBL963::Codoxy::Combunox::Numorphan::OXYMORPHONE::Opana::Oxycet::PERCODAN-DEMI::Percocet::Percodan::Roxicet::Roxilox::Roxiprin::Tylox::Tylox-325
SMILES: CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O
InChI Key: InChIKey=UQCNKQCJZOAFTQ-ISWURRPUSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor (GUINEA PIG) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting | Bioorg Med Chem Lett 21: 4104-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.147 BindingDB Entry DOI: 10.7270/Q25M66P3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (GUINEA PIG) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MeP... | J Med Chem 28: 974-6 (1985) BindingDB Entry DOI: 10.7270/Q27W6CSW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University La Sapienza Curated by ChEMBL | Assay Description Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranes | J Med Chem 48: 3372-8 (2005) Article DOI: 10.1021/jm040894o BindingDB Entry DOI: 10.7270/Q2X92C3R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting | J Med Chem 60: 9407-9412 (2017) Article DOI: 10.1021/acs.jmedchem.7b01363 BindingDB Entry DOI: 10.7270/Q2PZ5C72 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (MOUSE) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cells | ACS Med Chem Lett 3: 640-644 (2012) Article DOI: 10.1021/ml300083p BindingDB Entry DOI: 10.7270/Q2BR8T8V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (GUINEA PIG) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against Opioid receptor mu 1 of guinea pig brain membranes using 0.5 nM of [3H]naloxone as radioligand | J Med Chem 29: 1222-5 (1987) BindingDB Entry DOI: 10.7270/Q2M04606 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 23.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting | J Med Chem 60: 9407-9412 (2017) Article DOI: 10.1021/acs.jmedchem.7b01363 BindingDB Entry DOI: 10.7270/Q2PZ5C72 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 26.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor delta 1 at a a temperature 25 degree Celsius labeled with ... | J Med Chem 28: 974-6 (1985) BindingDB Entry DOI: 10.7270/Q27W6CSW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 57.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University Curated by ChEMBL | Assay Description Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation counting | Bioorg Med Chem Lett 21: 4104-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.147 BindingDB Entry DOI: 10.7270/Q25M66P3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 61.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University La Sapienza Curated by ChEMBL | Assay Description Inhibition of [3H]U-69593 binding to opioid receptor kappa from guinea pig brain membranes | J Med Chem 48: 3372-8 (2005) Article DOI: 10.1021/jm040894o BindingDB Entry DOI: 10.7270/Q2X92C3R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Displacement of [3H]-diprenorphine from recombinant human DOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting | J Med Chem 60: 9407-9412 (2017) Article DOI: 10.1021/acs.jmedchem.7b01363 BindingDB Entry DOI: 10.7270/Q2PZ5C72 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 80.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University La Sapienza Curated by ChEMBL | Assay Description Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranes | J Med Chem 48: 3372-8 (2005) Article DOI: 10.1021/jm040894o BindingDB Entry DOI: 10.7270/Q2X92C3R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor kappa 1 at temperature 25 degree Celsius labeled with (-)-... | J Med Chem 28: 974-6 (1985) BindingDB Entry DOI: 10.7270/Q27W6CSW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank PubMed | 145 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against Opioid receptor delta 1 of guinea pig brain membranes using 1 nM of [3H]DADLE as radioligand | J Med Chem 29: 1222-5 (1987) BindingDB Entry DOI: 10.7270/Q2M04606 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 208 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 435 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 724 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cells | ACS Med Chem Lett 3: 640-644 (2012) Article DOI: 10.1021/ml300083p BindingDB Entry DOI: 10.7270/Q2BR8T8V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 725 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against Opioid receptor kappa 1 of guinea pig brain membranes using 1 nM of (-)-[3H]ethylketazocine as radioligand | J Med Chem 29: 1222-5 (1987) BindingDB Entry DOI: 10.7270/Q2M04606 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | 730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from delta-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity to rat brain opioid receptor | J Med Chem 21: 101-6 (1978) Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptor (Rattus norvegicus (rat)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity to opiate receptor in rat brain homogenates | J Med Chem 22: 328-31 (1979) Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay | J Med Chem 60: 9407-9412 (2017) Article DOI: 10.1021/acs.jmedchem.7b01363 BindingDB Entry DOI: 10.7270/Q2PZ5C72 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptors; mu/kappa/delta (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane | J Med Chem 35: 4589-94 (1993) BindingDB Entry DOI: 10.7270/Q27S7PCK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane | J Med Chem 35: 4589-94 (1993) BindingDB Entry DOI: 10.7270/Q27S7PCK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (GUINEA PIG) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane | J Med Chem 35: 4589-94 (1993) BindingDB Entry DOI: 10.7270/Q27S7PCK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membrane | J Med Chem 35: 4589-94 (1993) BindingDB Entry DOI: 10.7270/Q27S7PCK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Solute carrier family 22 member 1 (Homo sapiens (Human)) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medicine Greifswald Curated by ChEMBL | Assay Description Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | J Med Chem 62: 9890-9905 (2019) Article DOI: 10.1021/acs.jmedchem.9b01301 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptor (Rattus norvegicus (rat)-RAT) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl | J Med Chem 27: 1575-9 (1984) BindingDB Entry DOI: 10.7270/Q2X92DHJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptor (Rattus norvegicus (rat)-RAT) | BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl | J Med Chem 27: 1575-9 (1984) BindingDB Entry DOI: 10.7270/Q2X92DHJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
