BDBM50001812 1-(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indol-1-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one::CHEMBL144318

SMILES: Fc1ccc(cc1)-c1cn(C2CCN(CCN3CCNC3=O)CC2)c2ccc(F)cc12

InChI Key: InChIKey=FKZJBKNKELKMSE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50001812   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50001812 (1-(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indol-1-yl]-...) Show SMILES Fc1ccc(cc1)-c1cn(C2CCN(CCN3CCNC3=O)CC2)c2ccc(F)cc12 Show InChI InChI=1S/C24H26F2N4O/c25-18-3-1-17(2-4-18)22-16-30(23-6-5-19(26)15-21(22)23)20-7-10-28(11-8-20)13-14-29-12-9-27-24(29)31/h1-6,15-16,20H,7-14H2,(H,27,31)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes				J Med Chem 35: 4823-31 (1993) BindingDB Entry DOI: 10.7270/Q2BK1B8P
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50001812 (1-(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indol-1-yl]-...) Show SMILES Fc1ccc(cc1)-c1cn(C2CCN(CCN3CCNC3=O)CC2)c2ccc(F)cc12 Show InChI InChI=1S/C24H26F2N4O/c25-18-3-1-17(2-4-18)22-16-30(23-6-5-19(26)15-21(22)23)20-7-10-28(11-8-20)13-14-29-12-9-27-24(29)31/h1-6,15-16,20H,7-14H2,(H,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes				J Med Chem 35: 4823-31 (1993) BindingDB Entry DOI: 10.7270/Q2BK1B8P
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50001812 (1-(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indol-1-yl]-...) Show SMILES Fc1ccc(cc1)-c1cn(C2CCN(CCN3CCNC3=O)CC2)c2ccc(F)cc12 Show InChI InChI=1S/C24H26F2N4O/c25-18-3-1-17(2-4-18)22-16-30(23-6-5-19(26)15-21(22)23)20-7-10-28(11-8-20)13-14-29-12-9-27-24(29)31/h1-6,15-16,20H,7-14H2,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Displacement of [3H]-spiperone from Dopamine receptor D2 rat striatal membranes				J Med Chem 35: 4823-31 (1993) BindingDB Entry DOI: 10.7270/Q2BK1B8P
					More data for this Ligand-Target Pair