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SMILES: Cc1cccc(Nc2sc(cc2C(N)=O)-c2ccc(F)cc2)n1

InChI Key: InChIKey=ACAOHWOPNZHWAF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003591   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50003591
PNG
(CHEMBL3234881)
Show SMILES Cc1cccc(Nc2sc(cc2C(N)=O)-c2ccc(F)cc2)n1
Show InChI InChI=1S/C17H14FN3OS/c1-10-3-2-4-15(20-10)21-17-13(16(19)22)9-14(23-17)11-5-7-12(18)8-6-11/h2-9H,1H3,(H2,19,22)(H,20,21)
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n/an/a 140n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin)

Bioorg Med Chem Lett 24: 1968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.064
BindingDB Entry DOI: 10.7270/Q2CF9RM3
More data for this
Ligand-Target Pair