BDBM50005908 CHEMBL3234707::US9062004, 14::US9670216, 14 4-Bromo-5-(2-dimethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one
SMILES: CN(C)CCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Br
InChI Key: InChIKey=ODCAZILQOIHJAU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK293 cells after 90 mins by liquid scintillation counting | Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 7.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]-CP55940 from human CB1 receptor expressed in HEK293 cells after 90 mins by liquid scintillation counting | Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Allergan, Inc. US Patent | Assay Description Plasma membranes prepared from HEK 293 EBNA cells transfected with human CB1 or CB2 cannabinoid receptors (3.7 or 3.3 .mu.mol/mg protein, receptor co... | US Patent US9062004 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64SM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | 25 |
ALLERGAN, INC. US Patent | Assay Description Plasma membranes prepared from HEK 293 EBNA cells transfected with human CB1 or CB2 cannabinoid receptors (3.7 or 3.3 pmol/mg protein, receptor conce... | US Patent US9670216 (2017) BindingDB Entry DOI: 10.7270/Q2V98674 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Mus musculus (Mouse)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 820 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at CB1 receptor in Swiss Webster mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction | Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 7.41E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
ALLERGAN, INC. US Patent | Assay Description Plasma membranes prepared from HEK 293 EBNA cells transfected with human CB1 or CB2 cannabinoid receptors (3.7 or 3.3 pmol/mg protein, receptor conce... | US Patent US9670216 (2017) BindingDB Entry DOI: 10.7270/Q2V98674 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50005908 (CHEMBL3234707 | US9062004, 14 | US9670216, 14 4-Br...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 7.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Allergan, Inc. US Patent | Assay Description Plasma membranes prepared from HEK 293 EBNA cells transfected with human CB1 or CB2 cannabinoid receptors (3.7 or 3.3 .mu.mol/mg protein, receptor co... | US Patent US9062004 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64SM | |||||||||||
More data for this Ligand-Target Pair |