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SMILES: CN1C(=O)Nc2cc(C)c(Cl)cc2C11NC(=O)NC1=O

InChI Key: InChIKey=JWAVNIBXSJBIOH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006362   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM50006362
PNG
(6'-chloro-3',7'-dimethyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2cc(C)c(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H11ClN4O3/c1-5-3-8-6(4-7(5)13)12(17(2)11(20)14-8)9(18)15-10(19)16-12/h3-4H,1-2H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 30n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens

J Med Chem 35: 2085-94 (1992)


BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair