BDBM50007158 (S)-2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone(BRL 52537)::2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone::CHEMBL71294
SMILES: Clc1ccc(CC(=O)N2CCCC[C@H]2CN2CCCC2)cc1Cl
InChI Key: InChIKey=GHCCBWMZKJQGLS-HNNXBMFYSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50007158 ((S)-2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylme...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zambeletti Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-U-69,593 from kappa opioid receptors in guine pig brain (minus cerebellum). | J Med Chem 34: 397-403 (1991) BindingDB Entry DOI: 10.7270/Q23777N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50007158 ((S)-2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylme...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zambeletti Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pig | J Med Chem 34: 2624-33 (1991) BindingDB Entry DOI: 10.7270/Q2CV4GPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50007158 ((S)-2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylme...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zambeletti Research Laboratories Curated by ChEMBL | Assay Description Affinity for opioid receptor delta sites | J Med Chem 34: 2624-33 (1991) BindingDB Entry DOI: 10.7270/Q2CV4GPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50007158 ((S)-2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylme...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zambeletti Research Laboratories Curated by ChEMBL | Assay Description Affinity for opioid receptor mu sites | J Med Chem 34: 2624-33 (1991) BindingDB Entry DOI: 10.7270/Q2CV4GPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50007158 ((S)-2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylme...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zambeletti Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-DAGO from mu opioid receptors in guinea pig brain (minus cerebellum). | J Med Chem 34: 397-403 (1991) BindingDB Entry DOI: 10.7270/Q23777N1 | |||||||||||
More data for this Ligand-Target Pair |