BDBM50007489 8-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethoxy]-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL273505

SMILES: O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1ncccn1

InChI Key: InChIKey=KWNSXONJJXBOFN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50007489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007489 (8-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethoxy]-8-a...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C19H27N5O3/c25-16-14-19(4-1-2-5-19)15-17(26)24(16)27-13-12-22-8-10-23(11-9-22)18-20-6-3-7-21-18/h3,6-7H,1-2,4-5,8-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue				J Med Chem 34: 1068-72 (1991) BindingDB Entry DOI: 10.7270/Q2D21Z6P
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50007489 (8-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethoxy]-8-a...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C19H27N5O3/c25-16-14-19(4-1-2-5-19)15-17(26)24(16)27-13-12-22-8-10-23(11-9-22)18-20-6-3-7-21-18/h3,6-7H,1-2,4-5,8-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.				J Med Chem 34: 1068-72 (1991) BindingDB Entry DOI: 10.7270/Q2D21Z6P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50007489 (8-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethoxy]-8-a...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCN1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C19H27N5O3/c25-16-14-19(4-1-2-5-19)15-17(26)24(16)27-13-12-22-8-10-23(11-9-22)18-20-6-3-7-21-18/h3,6-7H,1-2,4-5,8-15H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue				J Med Chem 34: 1068-72 (1991) BindingDB Entry DOI: 10.7270/Q2D21Z6P
					More data for this Ligand-Target Pair