null
SMILES: CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C)c(OC(=O)N(C)C)cc3oc2=O)c1
InChI Key: InChIKey=RCDMARDJTWRNQN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50010469![]() (CHEMBL3092179) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 mins | ACS Med Chem Lett 5: 309-14 (2014) Article DOI: 10.1021/ml400379x BindingDB Entry DOI: 10.7270/Q27W6DQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human)) | BDBM50010469![]() (CHEMBL3092179) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd Curated by ChEMBL | Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... | ACS Med Chem Lett 4: 1059-63 (2013) Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50010469![]() (CHEMBL3092179) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd Curated by ChEMBL | Assay Description Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay | ACS Med Chem Lett 4: 1059-63 (2013) Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ | |||||||||||
More data for this Ligand-Target Pair |