BDBM50010617 (-)-3-(1-Propyl-piperidin-3-yl)-phenol::(S)-3-(1-propylpiperidin-3-yl)phenol::3-((S)-1-Propyl-piperidin-3-yl)-phenol::3-(1-Propyl-piperidin-3-yl)-phenol::3PPP,(+)::CHEMBL7549::Preclamol
SMILES: CCCN1CCC[C@H](C1)c1cccc(O)c1
InChI Key: InChIKey=HTSNFXAICLXZMA-CYBMUJFWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian dopamine D2 autoreceptor, expressed in CHO-K1 cells, using [3H]U-86170 as radioligand | J Med Chem 37: 2735-53 (1994) BindingDB Entry DOI: 10.7270/Q2J96719 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against rat D2 short receptor | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against rat D2 long receptor | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch Sweden AB Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells | J Med Chem 53: 2510-20 (2010) Article DOI: 10.1021/jm901689v BindingDB Entry DOI: 10.7270/Q2NG4RKK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity to rat striatal Dopamine receptor D2 was determined using the agonist [3H]quinpirole to label the high affinity state (D2 h... | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against human Dopamine receptor D3 | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 short (high/low affinity is given as 27/1800) | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description Affinity against recombinant dopamine receptor (DA) D2 expressed in CHO-K1 cells, using [3H]-spiperone as radioligand | J Med Chem 37: 2735-53 (1994) BindingDB Entry DOI: 10.7270/Q2J96719 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University Curated by PDSP Ki Database | J Pharmacol Exp Ther 238: 739-48 (1986) BindingDB Entry DOI: 10.7270/Q2C24TX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University Curated by PDSP Ki Database | J Pharmacol Exp Ther 238: 739-48 (1986) BindingDB Entry DOI: 10.7270/Q2C24TX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranes | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by PDSP Ki Database | Proc Natl Acad Sci U S A 81: 4983-7 (1984) Article DOI: 10.1073/pnas.81.15.4983 BindingDB Entry DOI: 10.7270/Q2JM284N | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by PDSP Ki Database | J Pharm Pharmacol 38: 374-9 (1986) Article DOI: 10.1111/j.2042-7158.1986.tb04590.x BindingDB Entry DOI: 10.7270/Q2JS9NXW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro affinity against dopamine receptor D2 using [3H]DP-5,6-ADTN radioligand in rat striatal homogenate | J Med Chem 29: 1889-95 (1986) BindingDB Entry DOI: 10.7270/Q2ZC83F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description Affinity against striatal dopamine D2 receptors using [3H]spiperone as radioligand in rats. | J Med Chem 37: 2735-53 (1994) BindingDB Entry DOI: 10.7270/Q2J96719 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Illinois University Edwardsville Curated by ChEMBL | Assay Description Binding affinity to human dopamine D3 receptor | Bioorg Med Chem Lett 28: 1897-1902 (2018) Article DOI: 10.1016/j.bmcl.2018.03.084 BindingDB Entry DOI: 10.7270/Q2F47RS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description Tested for in vitro binding affinity against cloned mammalian dopamine D3 receptor, expressed in CHO-K1 cells, using [3H]spiperone as radioligand | J Med Chem 37: 2735-53 (1994) BindingDB Entry DOI: 10.7270/Q2J96719 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Illinois University Edwardsville Curated by ChEMBL | Assay Description Binding affinity to human dopamine D2 receptor | Bioorg Med Chem Lett 28: 1897-1902 (2018) Article DOI: 10.1016/j.bmcl.2018.03.084 BindingDB Entry DOI: 10.7270/Q2F47RS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 234 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDA-IRP Curated by ChEMBL | Assay Description Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligand | J Med Chem 46: 2589-98 (2003) Article DOI: 10.1021/jm030008u BindingDB Entry DOI: 10.7270/Q2H70GJN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity site | J Med Chem 41: 4933-8 (1999) Article DOI: 10.1021/jm9708700 BindingDB Entry DOI: 10.7270/Q2FJ2HGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 702 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity to rat striatal Dopamine receptor D2 was determined using the antagonist [3H]spiperone + GTP to label the low affinity stat... | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Tested for binding affinity against Dopamine receptor D2 like from bovine striatum membranes by using [3H]YM-09151-2 radioligand | J Med Chem 41: 4933-8 (1999) Article DOI: 10.1021/jm9708700 BindingDB Entry DOI: 10.7270/Q2FJ2HGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch Sweden AB Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells | J Med Chem 53: 2510-20 (2010) Article DOI: 10.1021/jm901689v BindingDB Entry DOI: 10.7270/Q2NG4RKK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDA-IRP Curated by ChEMBL | Assay Description Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brain | J Med Chem 46: 2589-98 (2003) Article DOI: 10.1021/jm030008u BindingDB Entry DOI: 10.7270/Q2H70GJN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description Tested for affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT in homogenized rat brain tissue | J Med Chem 37: 2735-53 (1994) BindingDB Entry DOI: 10.7270/Q2J96719 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Imidazoline I1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by PDSP Ki Database | J Pharmacol Exp Ther 285: 170-7 (1998) BindingDB Entry DOI: 10.7270/Q27H1H4B | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University Curated by PDSP Ki Database | J Pharmacol Exp Ther 238: 739-48 (1986) BindingDB Entry DOI: 10.7270/Q2C24TX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University Curated by PDSP Ki Database | J Pharmacol Exp Ther 238: 739-48 (1986) BindingDB Entry DOI: 10.7270/Q2C24TX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, low affinity site | J Med Chem 41: 4933-8 (1999) Article DOI: 10.1021/jm9708700 BindingDB Entry DOI: 10.7270/Q2FJ2HGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 376 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +... | J Med Chem 58: 9179-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01031 BindingDB Entry DOI: 10.7270/Q2N019HB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 844 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/-... | J Med Chem 58: 9179-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01031 BindingDB Entry DOI: 10.7270/Q2N019HB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | J Med Chem 58: 9179-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01031 BindingDB Entry DOI: 10.7270/Q2N019HB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against rat D2 long receptor | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Bari Curated by ChEMBL | Assay Description Ability to displace [3H]spiroperidol, from dopamine receptor D2 specific binding sites of rat striatal membranes | J Med Chem 35: 3045-9 (1992) BindingDB Entry DOI: 10.7270/Q2JD4XDS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lund Curated by ChEMBL | Assay Description In vitro inhibition of [3H]-N-0437 binding to Dopamine receptor D2 in rat striatal membranes | J Med Chem 33: 1015-22 (1990) BindingDB Entry DOI: 10.7270/Q2PV6JBT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 163 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | J Med Chem 58: 9179-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01031 BindingDB Entry DOI: 10.7270/Q2N019HB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand | J Med Chem 30: 2169-74 (1988) BindingDB Entry DOI: 10.7270/Q2MW2HQJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against human D3 receptor | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Displacement of (+)-3PPP from sigma receptor of rat brain membrane | J Med Chem 37: 1727-32 (1994) Checked by Author BindingDB Entry DOI: 10.7270/Q25B0408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Displacement of spiperone from dopamine receptor D2 of rat brain membrane | J Med Chem 37: 1727-32 (1994) Checked by Author BindingDB Entry DOI: 10.7270/Q25B0408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against human D4.2 receptor | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Friedrich-Alexander University Curated by ChEMBL | Assay Description Effective concentration required for agonistic activity against rat D2 long receptor | Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lund Curated by ChEMBL | Assay Description In vitro inhibition of [3H]-spiperone binding to Dopamine receptor D2 in rat striatal membranes | J Med Chem 33: 1015-22 (1990) BindingDB Entry DOI: 10.7270/Q2PV6JBT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
University of G£teborg Curated by ChEMBL | Assay Description In vitro for binding affinity against sigma receptor using [3H](+)-3-PPP as radioligand | J Med Chem 30: 2169-74 (1988) BindingDB Entry DOI: 10.7270/Q2MW2HQJ | |||||||||||
More data for this Ligand-Target Pair |