BDBM50012893 2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-hydroxy-acetamide::2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-hydroxy-acetamide(Indomethacin series)::2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}ethanehydroxamic acid::CHEMBL295829::Oxametacin
SMILES: COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NO)c2c1
InChI Key: InChIKey=AJRNYCDWNITGHF-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50012893![]() (2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of 5-lipoxygenase in intact RBL-1 cell line | J Med Chem 33: 2070-2 (1990) BindingDB Entry DOI: 10.7270/Q2RJ4HGZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50012893![]() (2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for inhibition of 5-Lipoxygenase (ARBL) in calcium-stimulated rat basophillic leukemia cells(RBL-1) | Bioorg Med Chem Lett 2: 1655-1660 (1992) Article DOI: 10.1016/S0960-894X(00)80450-3 BindingDB Entry DOI: 10.7270/Q2TD9X9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase (RAT) | BDBM50012893![]() (2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for inhibition of cyclooxygenase (ARBC) in calcium-stimulated rat basophilic leukemia cells(RBL-1) | Bioorg Med Chem Lett 2: 1655-1660 (1992) Article DOI: 10.1016/S0960-894X(00)80450-3 BindingDB Entry DOI: 10.7270/Q2TD9X9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase (RAT) | BDBM50012893![]() (2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line | J Med Chem 33: 2070-2 (1990) BindingDB Entry DOI: 10.7270/Q2RJ4HGZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human)) | BDBM50012893![]() (2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NitroMed, Inc. Curated by ChEMBL | Assay Description Inhibition of COX1 in human whole blood assessed as effect on A23187-induced thromboxane B2 production | J Med Chem 50: 6367-82 (2007) Article DOI: 10.1021/jm0611861 BindingDB Entry DOI: 10.7270/Q2RJ4K9J | |||||||||||
More data for this Ligand-Target Pair |