BDBM50019676 2-Methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (4-pyridin-3-yl-butyl)-amide::CHEMBL300338

SMILES: Cc1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCc1cccnc1

InChI Key: InChIKey=OIMUMJMHBPPFFI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50019676   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50019676 (2-Methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-car...) Show SMILES Cc1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCc1cccnc1 Show InChI InChI=1S/C23H22N4O2/c1-16-7-9-20-19(13-16)23(29)27-15-18(8-10-21(27)26-20)22(28)25-12-3-2-5-17-6-4-11-24-14-17/h4,6-11,13-15H,2-3,5,12H2,1H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets				J Med Chem 30: 185-93 (1987) BindingDB Entry DOI: 10.7270/Q2222VBH
					More data for this Ligand-Target Pair
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50019676 (2-Methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-car...) Show SMILES Cc1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCc1cccnc1 Show InChI InChI=1S/C23H22N4O2/c1-16-7-9-20-19(13-16)23(29)27-15-18(8-10-21(27)26-20)22(28)25-12-3-2-5-17-6-4-11-24-14-17/h4,6-11,13-15H,2-3,5,12H2,1H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand				J Med Chem 31: 466-72 (1988) BindingDB Entry DOI: 10.7270/Q2KK99S6
					More data for this Ligand-Target Pair