BDBM50020242 CHEMBL3288507::US9914707, I-19

SMILES: Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12

InChI Key: InChIKey=YBNCMEUCGIRINC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50020242   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020242 (CHEMBL3288507 | US9914707, I-19) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12 Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020242 (CHEMBL3288507 | US9914707, I-19) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12 Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...				J Med Chem 51: 725-36 (2008) BindingDB Entry DOI: 10.7270/Q2DR2XS5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020242 (CHEMBL3288507 | US9914707, I-19) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12 Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair