BDBM50023932 CHEMBL3325499

SMILES: CN1CCC(CC1)N1CC[C@@H](C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1

InChI Key: InChIKey=RVRQRQKTOQUXNF-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50023932   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 2 (Homo sapiens (Human))	BDBM50023932 (CHEMBL3325499) Show SMILES CN1CCC(CC1)N1CC[C@@H](C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C25H30F3N3O2/c1-30-13-11-22(12-14-30)31-15-10-21(16-31)29-24(32)19-4-2-18(3-5-19)17-33-23-8-6-20(7-9-23)25(26,27)28/h2-9,21-22H,10-17H2,1H3,(H,29,32)/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs				Bioorg Med Chem Lett 24: 4603-6 (2014) Article DOI: 10.1016/j.bmcl.2014.06.059 BindingDB Entry DOI: 10.7270/Q2K64KN1
					More data for this Ligand-Target Pair