BDBM50023973 CHEMBL3325496

SMILES: CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(Cl)cc2Cl)cc1

InChI Key: InChIKey=XNDVKZIHBSAUMX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50023973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 2 (Homo sapiens (Human))	BDBM50023973 (CHEMBL3325496) Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C24H29Cl2N3O2/c1-28-11-9-21(10-12-28)29-13-8-20(15-29)27-24(30)18-4-2-17(3-5-18)16-31-23-7-6-19(25)14-22(23)26/h2-7,14,20-21H,8-13,15-16H2,1H3,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	431	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs				Bioorg Med Chem Lett 24: 4603-6 (2014) Article DOI: 10.1016/j.bmcl.2014.06.059 BindingDB Entry DOI: 10.7270/Q2K64KN1
					More data for this Ligand-Target Pair