BDBM50025976 3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one::CHEMBL168453

SMILES: Clc1c(oc2ccccc2c1=O)-c1nnn[nH]1

InChI Key: InChIKey=LPKGQHBYVFYNTI-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50025976   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50025976 (3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one | CHEM...) Show SMILES Clc1c(oc2ccccc2c1=O)-c1nnn[nH]1 Show InChI InChI=1S/C10H5ClN4O2/c11-7-8(16)5-3-1-2-4-6(5)17-9(7)10-12-14-15-13-10/h1-4H,(H,12,13,14,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 2				J Med Chem 28: 841-9 (1985) BindingDB Entry DOI: 10.7270/Q2J965DD
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50025976 (3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one | CHEM...) Show SMILES Clc1c(oc2ccccc2c1=O)-c1nnn[nH]1 Show InChI InChI=1S/C10H5ClN4O2/c11-7-8(16)5-3-1-2-4-6(5)17-9(7)10-12-14-15-13-10/h1-4H,(H,12,13,14,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human placental aldose reductase in 30 -70% (NH4)2SO4.				J Med Chem 28: 841-9 (1985) BindingDB Entry DOI: 10.7270/Q2J965DD
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50025976 (3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one | CHEM...) Show SMILES Clc1c(oc2ccccc2c1=O)-c1nnn[nH]1 Show InChI InChI=1S/C10H5ClN4O2/c11-7-8(16)5-3-1-2-4-6(5)17-9(7)10-12-14-15-13-10/h1-4H,(H,12,13,14,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human placental aldose reductase in 30 -70% (NH4)2SO4.				J Med Chem 28: 841-9 (1985) BindingDB Entry DOI: 10.7270/Q2J965DD
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50025976 (3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one | CHEM...) Show SMILES Clc1c(oc2ccccc2c1=O)-c1nnn[nH]1 Show InChI InChI=1S/C10H5ClN4O2/c11-7-8(16)5-3-1-2-4-6(5)17-9(7)10-12-14-15-13-10/h1-4H,(H,12,13,14,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7				J Med Chem 28: 841-9 (1985) BindingDB Entry DOI: 10.7270/Q2J965DD
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50025976 (3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one | CHEM...) Show SMILES Clc1c(oc2ccccc2c1=O)-c1nnn[nH]1 Show InChI InChI=1S/C10H5ClN4O2/c11-7-8(16)5-3-1-2-4-6(5)17-9(7)10-12-14-15-13-10/h1-4H,(H,12,13,14,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at time 1				J Med Chem 28: 841-9 (1985) BindingDB Entry DOI: 10.7270/Q2J965DD
					More data for this Ligand-Target Pair