BDBM50029418 CHEMBL275195::[4-(2,4-Dimethoxy-phenyl)-4H-benzo[b]pyrrolo[1,2-d][1,4]thiazin-1-ylmethyl]-dimethyl-amine

SMILES: COc1ccc(C2Sc3ccccc3-n3c(CN(C)C)ccc23)c(OC)c1

InChI Key: InChIKey=ICMCIDYUTSXGGO-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50029418   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50029418 (CHEMBL275195 | [4-(2,4-Dimethoxy-phenyl)-4H-benzo[...) Show SMILES COc1ccc(C2Sc3ccccc3-n3c(CN(C)C)ccc23)c(OC)c1 Show InChI InChI=1S/C22H24N2O2S/c1-23(2)14-15-9-12-19-22(17-11-10-16(25-3)13-20(17)26-4)27-21-8-6-5-7-18(21)24(15)19/h5-13,22H,14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]nitrendipine from calcium channel receptor				Citation and Details BindingDB Entry DOI: 10.7270/Q2F47RB8
					More data for this Ligand-Target Pair
Calcium channel (RAT)	BDBM50029418 (CHEMBL275195 | [4-(2,4-Dimethoxy-phenyl)-4H-benzo[...) Show SMILES COc1ccc(C2Sc3ccccc3-n3c(CN(C)C)ccc23)c(OC)c1 Show InChI InChI=1S/C22H24N2O2S/c1-23(2)14-15-9-12-19-22(17-11-10-16(25-3)13-20(17)26-4)27-21-8-6-5-7-18(21)24(15)19/h5-13,22H,14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Siena Curated by ChEMBL					Assay Description Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channel				J Med Chem 38: 4393-410 (1995) BindingDB Entry DOI: 10.7270/Q24M93JW
					More data for this Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex (Rattus norvegicus)	BDBM50029418 (CHEMBL275195 | [4-(2,4-Dimethoxy-phenyl)-4H-benzo[...) Show SMILES COc1ccc(C2Sc3ccccc3-n3c(CN(C)C)ccc23)c(OC)c1 Show InChI InChI=1S/C22H24N2O2S/c1-23(2)14-15-9-12-19-22(17-11-10-16(25-3)13-20(17)26-4)27-21-8-6-5-7-18(21)24(15)19/h5-13,22H,14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Universita' degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50				J Med Chem 40: 125-31 (1997) Article DOI: 10.1021/jm9605647 BindingDB Entry DOI: 10.7270/Q2JQ128M
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50029418 (CHEMBL275195 | [4-(2,4-Dimethoxy-phenyl)-4H-benzo[...) Show SMILES COc1ccc(C2Sc3ccccc3-n3c(CN(C)C)ccc23)c(OC)c1 Show InChI InChI=1S/C22H24N2O2S/c1-23(2)14-15-9-12-19-22(17-11-10-16(25-3)13-20(17)26-4)27-21-8-6-5-7-18(21)24(15)19/h5-13,22H,14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]nitrendipine from calcium channel receptor				Citation and Details BindingDB Entry DOI: 10.7270/Q2F47RB8
					More data for this Ligand-Target Pair