BDBM50033847 CHEMBL108241::{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-amine

SMILES: COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC

InChI Key: InChIKey=FVDGLILSFMGSJG-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50033847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand				J Med Chem 38: 942-9 (1995) BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	618	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.				J Med Chem 38: 942-9 (1995) BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.01	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.				J Med Chem 38: 942-9 (1995) BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Bari Curated by ChEMBL					Assay Description Compound was evaluated for their affinity against Dopamine receptor D2 by displacing [3H]spiperone in rat striatal membrane				J Med Chem 39: 3195-202 (1996) Article DOI: 10.1021/jm960087s BindingDB Entry DOI: 10.7270/Q2GM87ZN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-8-OH-DPAT binding to rat 5-HT 1a receptors.				J Med Chem 42: 490-6 (1999) Article DOI: 10.1021/jm980420n BindingDB Entry DOI: 10.7270/Q29W0DP9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Bari Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand				J Med Chem 39: 3195-202 (1996) Article DOI: 10.1021/jm960087s BindingDB Entry DOI: 10.7270/Q2GM87ZN
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50033847 (CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...) Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-spiroperidol binding to rat Dopamine D2 receptors.				J Med Chem 42: 490-6 (1999) Article DOI: 10.1021/jm980420n BindingDB Entry DOI: 10.7270/Q29W0DP9
					More data for this Ligand-Target Pair