BDBM50036205 CHEMBL3358692

SMILES: COc1ccc(Cl)cc1Nc1nnc(o1)-c1csc(NC(=O)C(C)(C)C)n1

InChI Key: InChIKey=PGHAPOMUONNUTB-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50036205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50036205 (CHEMBL3358692) Show SMILES COc1ccc(Cl)cc1Nc1nnc(o1)-c1csc(NC(=O)C(C)(C)C)n1 Show InChI InChI=1S/C17H18ClN5O3S/c1-17(2,3)14(24)21-16-20-11(8-27-16)13-22-23-15(26-13)19-10-7-9(18)5-6-12(10)25-4/h5-8H,1-4H3,(H,19,23)(H,20,21,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	660	n/a	n/a	n/a	n/a
Wuhan University of Science and Technology Curated by ChEMBL					Assay Description Activity of human CFTR F508 deletion mutant expressed in FRT cells assessed as potentiation of genistein-induced iodine ion influx after 24 hrs by YF...				Bioorg Med Chem Lett 24: 5840-4 (2014) Article DOI: 10.1016/j.bmcl.2014.09.067 BindingDB Entry DOI: 10.7270/Q27H1M6G
					More data for this Ligand-Target Pair