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SMILES: Cc1cccc2c(cc(C(=O)c3ccc(Br)cc3)n12)C(=O)OCCC#C

InChI Key: InChIKey=WSYJULVMQZWCGY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50036270   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50036270
PNG
(CHEMBL3361094)
Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Br)cc3)n12)C(=O)OCCC#C
Show InChI InChI=1S/C21H16BrNO3/c1-3-4-12-26-21(25)17-13-19(23-14(2)6-5-7-18(17)23)20(24)15-8-10-16(22)11-9-15/h1,5-11,13H,4,12H2,2H3
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Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Alexandru Ioan Cuza University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay

Bioorg Med Chem Lett 24: 5777-81 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.044
BindingDB Entry DOI: 10.7270/Q2W95BTK
More data for this
Ligand-Target Pair