BDBM50036534 CHEMBL3353592

SMILES: OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F

InChI Key: InChIKey=CDRBZUVBPKPRTA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50036534   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50036534 (CHEMBL3353592) Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O4S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-13-3-1-2-4-16(13)21(26,27)28)35(33,34)15-7-5-12(6-8-15)19(31)32/h1-10H,11H2,(H,31,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
RaQualia Pharma Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx				Bioorg Med Chem Lett 24: 5364-8 (2014) Article DOI: 10.1016/j.bmcl.2014.10.074 BindingDB Entry DOI: 10.7270/Q2TB18HX
					More data for this Ligand-Target Pair