BDBM50039669 1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10-yl]-4-methyl-piperazine::CHEMBL90977

SMILES: C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12

InChI Key: InChIKey=DISSGPVGANAWAA-ZUWFHJRGSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50039669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT)	BDBM50039669 (1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10...) Show SMILES C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12 |t:10| Show InChI InChI=1S/C22H24N2/c1-3-18-19-9-5-4-8-17(19)16-22(21-11-7-6-10-20(18)21)24-14-12-23(2)13-15-24/h3-11,16H,12-15H2,1-2H3/b18-3-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Affinity was evaluated by inhibition of [3H]-GR-65,630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptor				J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50039669 (1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10...) Show SMILES C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12 |t:10| Show InChI InChI=1S/C22H24N2/c1-3-18-19-9-5-4-8-17(19)16-22(21-11-7-6-10-20(18)21)24-14-12-23(2)13-15-24/h3-11,16H,12-15H2,1-2H3/b18-3-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Affinity of the compound was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand				J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50039669 (1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10...) Show SMILES C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12 |t:10| Show InChI InChI=1S/C22H24N2/c1-3-18-19-9-5-4-8-17(19)16-22(21-11-7-6-10-20(18)21)24-14-12-23(2)13-15-24/h3-11,16H,12-15H2,1-2H3/b18-3-	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Affinity was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptor				J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50039669 (1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10...) Show SMILES C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12 |t:10| Show InChI InChI=1S/C22H24N2/c1-3-18-19-9-5-4-8-17(19)16-22(21-11-7-6-10-20(18)21)24-14-12-23(2)13-15-24/h3-11,16H,12-15H2,1-2H3/b18-3-	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Affinity of the compound was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C recept...				J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50039669 (1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10...) Show SMILES C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12 |t:10| Show InChI InChI=1S/C22H24N2/c1-3-18-19-9-5-4-8-17(19)16-22(21-11-7-6-10-20(18)21)24-14-12-23(2)13-15-24/h3-11,16H,12-15H2,1-2H3/b18-3-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptor				J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50039669 (1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10...) Show SMILES C\C=C1\c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12 |t:10| Show InChI InChI=1S/C22H24N2/c1-3-18-19-9-5-4-8-17(19)16-22(21-11-7-6-10-20(18)21)24-14-12-23(2)13-15-24/h3-11,16H,12-15H2,1-2H3/b18-3-	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	730	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-2(long) receptor				J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX
					More data for this Ligand-Target Pair