BDBM50040921 5,6-Bis-(4-diethylamino-phenylamino)-isoindole-1,3-dione::CHEMBL8223

SMILES: CCN(CC)c1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(cc2)N(CC)CC)cc1

InChI Key: InChIKey=ZIUKVZLABPRJTA-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50040921   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50040921 (5,6-Bis-(4-diethylamino-phenylamino)-isoindole-1,3...) Show SMILES CCN(CC)c1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(cc2)N(CC)CC)cc1 Show InChI InChI=1S/C28H33N5O2/c1-5-32(6-2)21-13-9-19(10-14-21)29-25-17-23-24(28(35)31-27(23)34)18-26(25)30-20-11-15-22(16-12-20)33(7-3)8-4/h9-18,29-30H,5-8H2,1-4H3,(H,31,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Limited Curated by ChEMBL					Assay Description Inhibitory activity against c-src tyrosine kinase				J Med Chem 37: 1015-27 (1994) BindingDB Entry DOI: 10.7270/Q2M32TTP
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50040921 (5,6-Bis-(4-diethylamino-phenylamino)-isoindole-1,3...) Show SMILES CCN(CC)c1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(cc2)N(CC)CC)cc1 Show InChI InChI=1S/C28H33N5O2/c1-5-32(6-2)21-13-9-19(10-14-21)29-25-17-23-24(28(35)31-27(23)34)18-26(25)30-20-11-15-22(16-12-20)33(7-3)8-4/h9-18,29-30H,5-8H2,1-4H3,(H,31,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Limited Curated by ChEMBL					Assay Description Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD)				J Med Chem 37: 1015-27 (1994) BindingDB Entry DOI: 10.7270/Q2M32TTP
					More data for this Ligand-Target Pair
Cyclic AMP-dependent protein kinase (PKA) (Oryctolagus cuniculus (Rabbit))	BDBM50040921 (5,6-Bis-(4-diethylamino-phenylamino)-isoindole-1,3...) Show SMILES CCN(CC)c1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(cc2)N(CC)CC)cc1 Show InChI InChI=1S/C28H33N5O2/c1-5-32(6-2)21-13-9-19(10-14-21)29-25-17-23-24(28(35)31-27(23)34)18-26(25)30-20-11-15-22(16-12-20)33(7-3)8-4/h9-18,29-30H,5-8H2,1-4H3,(H,31,34,35)	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Limited Curated by ChEMBL					Assay Description Inhibitory activity was determined against protein kinase A (PKA) of rabbit				J Med Chem 37: 1015-27 (1994) BindingDB Entry DOI: 10.7270/Q2M32TTP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL (Homo sapiens (Human))	BDBM50040921 (5,6-Bis-(4-diethylamino-phenylamino)-isoindole-1,3...) Show SMILES CCN(CC)c1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(cc2)N(CC)CC)cc1 Show InChI InChI=1S/C28H33N5O2/c1-5-32(6-2)21-13-9-19(10-14-21)29-25-17-23-24(28(35)31-27(23)34)18-26(25)30-20-11-15-22(16-12-20)33(7-3)8-4/h9-18,29-30H,5-8H2,1-4H3,(H,31,34,35)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Limited Curated by ChEMBL					Assay Description Inhibitory activity against v-abl tyrosine kinase				J Med Chem 37: 1015-27 (1994) BindingDB Entry DOI: 10.7270/Q2M32TTP
					More data for this Ligand-Target Pair