BDBM50041911 CHEMBL3358932

SMILES: CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N1CCOCC1)C(F)(F)F)c1ccccc1

InChI Key: InChIKey=QDMKBJCCHCGTOQ-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50041911   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50041911 (CHEMBL3358932) Show SMILES CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N1CCOCC1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C24H28F3N3O2/c1-22(2,18-6-4-3-5-7-18)16-23(31,24(25,26)27)14-19-12-17-13-21(28-15-20(17)29-19)30-8-10-32-11-9-30/h3-7,12-13,15,29,31H,8-11,14,16H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of RU-486 from GR (unknown origin) by fluorescence polarization assay				ACS Med Chem Lett 5: 1318-23 (2014) Article DOI: 10.1021/ml500387y BindingDB Entry DOI: 10.7270/Q2639RCZ
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50041911 (CHEMBL3358932) Show SMILES CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N1CCOCC1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C24H28F3N3O2/c1-22(2,18-6-4-3-5-7-18)16-23(31,24(25,26)27)14-19-12-17-13-21(28-15-20(17)29-19)30-8-10-32-11-9-30/h3-7,12-13,15,29,31H,8-11,14,16H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of tetramethylrhodamine-labeled dexamethasone from PR (unknown origin) by fluorescence polarization assay				ACS Med Chem Lett 5: 1318-23 (2014) Article DOI: 10.1021/ml500387y BindingDB Entry DOI: 10.7270/Q2639RCZ
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50041911 (CHEMBL3358932) Show SMILES CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N1CCOCC1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C24H28F3N3O2/c1-22(2,18-6-4-3-5-7-18)16-23(31,24(25,26)27)14-19-12-17-13-21(28-15-20(17)29-19)30-8-10-32-11-9-30/h3-7,12-13,15,29,31H,8-11,14,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of RU-486 from MR (unknown origin) by fluorescence polarization assay				ACS Med Chem Lett 5: 1318-23 (2014) Article DOI: 10.1021/ml500387y BindingDB Entry DOI: 10.7270/Q2639RCZ
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50041911 (CHEMBL3358932) Show SMILES CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N1CCOCC1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C24H28F3N3O2/c1-22(2,18-6-4-3-5-7-18)16-23(31,24(25,26)27)14-19-12-17-13-21(28-15-20(17)29-19)30-8-10-32-11-9-30/h3-7,12-13,15,29,31H,8-11,14,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human recombinant CYP3A4 using 7-benzyloxy-4-(trifluoromethyl)-coumarin as substrate after 30 mins by fluorescence assay				ACS Med Chem Lett 5: 1318-23 (2014) Article DOI: 10.1021/ml500387y BindingDB Entry DOI: 10.7270/Q2639RCZ
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50041911 (CHEMBL3358932) Show SMILES CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N1CCOCC1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C24H28F3N3O2/c1-22(2,18-6-4-3-5-7-18)16-23(31,24(25,26)27)14-19-12-17-13-21(28-15-20(17)29-19)30-8-10-32-11-9-30/h3-7,12-13,15,29,31H,8-11,14,16H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production				ACS Med Chem Lett 5: 1318-23 (2014) Article DOI: 10.1021/ml500387y BindingDB Entry DOI: 10.7270/Q2639RCZ
					More data for this Ligand-Target Pair