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BDBM50043889 1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propyl]-4-(3-trifluoromethyl-phenyl)-piperazine::CHEMBL8507

SMILES: COc1ccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc2c1

InChI Key: InChIKey=RTTLUSMWCVHYGQ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50043889   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50043889
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc2c1 |c:27|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-10-11-24-19(5-2-6-20(24)17-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(18-22)25(26,27)28/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
PDB

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KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 1.29E+3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes


J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50043889
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc2c1 |c:27|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-10-11-24-19(5-2-6-20(24)17-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(18-22)25(26,27)28/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 138n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex


J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair