BDBM50048220 CHEMBL35992::N-[1-Oxo-6-(pyridin-2-ylsulfanyl)-indan-5-yl]-methanesulfonamide

SMILES: CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccccn1

InChI Key: InChIKey=URWLQWBEXRFSCD-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50048220   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human))	BDBM50048220 (CHEMBL35992 | N-[1-Oxo-6-(pyridin-2-ylsulfanyl)-in...) Show SMILES CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccccn1 Show InChI InChI=1S/C15H14N2O3S2/c1-22(19,20)17-12-8-10-5-6-13(18)11(10)9-14(12)21-15-4-2-3-7-16-15/h2-4,7-9,17H,5-6H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of Prostaglandin G/H synthase 1 activity in U937 microsomal assay				Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50048220 (CHEMBL35992 | N-[1-Oxo-6-(pyridin-2-ylsulfanyl)-in...) Show SMILES CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccccn1 Show InChI InChI=1S/C15H14N2O3S2/c1-22(19,20)17-12-8-10-5-6-13(18)11(10)9-14(12)21-15-4-2-3-7-16-15/h2-4,7-9,17H,5-6H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description In vitro inhibition of prostaglandin G/H synthase 2 expressed in human osteosarcoma 143 cells				J Med Chem 38: 4897-905 (1996) BindingDB Entry DOI: 10.7270/Q28051PC
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50048220 (CHEMBL35992 | N-[1-Oxo-6-(pyridin-2-ylsulfanyl)-in...) Show SMILES CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccccn1 Show InChI InChI=1S/C15H14N2O3S2/c1-22(19,20)17-12-8-10-5-6-13(18)11(10)9-14(12)21-15-4-2-3-7-16-15/h2-4,7-9,17H,5-6H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells				Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM
					More data for this Ligand-Target Pair
Prostaglandin E synthase/G/H synthase 2 (Homo sapiens (Human))	BDBM50048220 (CHEMBL35992 | N-[1-Oxo-6-(pyridin-2-ylsulfanyl)-in...) Show SMILES CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccccn1 Show InChI InChI=1S/C15H14N2O3S2/c1-22(19,20)17-12-8-10-5-6-13(18)11(10)9-14(12)21-15-4-2-3-7-16-15/h2-4,7-9,17H,5-6H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of Prostaglandin G/H synthase 1 activity in U937 microsomal assay				Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50048220 (CHEMBL35992 | N-[1-Oxo-6-(pyridin-2-ylsulfanyl)-in...) Show SMILES CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccccn1 Show InChI InChI=1S/C15H14N2O3S2/c1-22(19,20)17-12-8-10-5-6-13(18)11(10)9-14(12)21-15-4-2-3-7-16-15/h2-4,7-9,17H,5-6H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells				Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM
					More data for this Ligand-Target Pair