BDBM50049204 2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbonylaminosulphonyl)-biphenyl-4-ylmethyl)-6-(N-isopropyl-N-methyl-aminocarbonylamino)-3H-quinazolin-4-one::4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-4H-quinazolin-3-ylmethyl]-3'-fluoro-biphenyl-2-sulfonic acid cyclopropylethyloxycarbonylamide(L-163579)::CHEMBL73876::L-163579

SMILES: CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1

InChI Key: InChIKey=RGVQQWBCJAHMTA-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50049204   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Type-1 angiotensin II receptor (RABBIT)	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Angiotensin II receptor, type 1				J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane				Bioorg Med Chem Lett 4: 2337-2342 (1994) Article DOI: 10.1016/0960-894X(94)85036-4 BindingDB Entry DOI: 10.7270/Q2X066Z9
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane				Bioorg Med Chem Lett 4: 2337-2342 (1994) Article DOI: 10.1016/0960-894X(94)85036-4 BindingDB Entry DOI: 10.7270/Q2X066Z9
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A/B (RAT)	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane				Bioorg Med Chem Lett 4: 2337-2342 (1994) Article DOI: 10.1016/0960-894X(94)85036-4 BindingDB Entry DOI: 10.7270/Q2X066Z9
					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane				Bioorg Med Chem Lett 4: 2337-2342 (1994) Article DOI: 10.1016/0960-894X(94)85036-4 BindingDB Entry DOI: 10.7270/Q2X066Z9
					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibitory activity at Angiotensin II type 2 receptor.				J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299
					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane				Bioorg Med Chem Lett 4: 2337-2342 (1994) Article DOI: 10.1016/0960-894X(94)85036-4 BindingDB Entry DOI: 10.7270/Q2X066Z9
					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (Homo sapiens (Human))	BDBM50049204 (2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...) Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1 Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane				Bioorg Med Chem Lett 4: 2337-2342 (1994) Article DOI: 10.1016/0960-894X(94)85036-4 BindingDB Entry DOI: 10.7270/Q2X066Z9
					More data for this Ligand-Target Pair