BDBM50051823 CHEMBL275378::[(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone
SMILES: COCC[C@H]1CN(CCN1C[C@@H](N)CS)C(=O)c1cccc2ccccc12
InChI Key: InChIKey=GKTZPBPAMFCBNI-MSOLQXFVSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human)) | BDBM50051823 (CHEMBL275378 | [(S)-4-((R)-2-Amino-3-mercapto-prop...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into Ha-Ras by Farnesyltransferase | J Med Chem 39: 1345-8 (1996) Article DOI: 10.1021/jm9508090 BindingDB Entry DOI: 10.7270/Q2B8576Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50051823 (CHEMBL275378 | [(S)-4-((R)-2-Amino-3-mercapto-prop...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of post-traslational processing of Ras protein in RAT1 cell line | J Med Chem 39: 1345-8 (1996) Article DOI: 10.1021/jm9508090 BindingDB Entry DOI: 10.7270/Q2B8576Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50051823 (CHEMBL275378 | [(S)-4-((R)-2-Amino-3-mercapto-prop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of Farnesyltransferase | Bioorg Med Chem Lett 10: 273-5 (2000) BindingDB Entry DOI: 10.7270/Q26W999M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine)) | BDBM50051823 (CHEMBL275378 | [(S)-4-((R)-2-Amino-3-mercapto-prop...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of bovine Geranylgeranyl transferase type I | J Med Chem 39: 1345-8 (1996) Article DOI: 10.1021/jm9508090 BindingDB Entry DOI: 10.7270/Q2B8576Z | |||||||||||
More data for this Ligand-Target Pair |