BindingDB PrimarySearch

null

SMILES: CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23

InChI Key: InChIKey=LUZOFMGZMUZSSK-LRDDRELGSA-N

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 71 hits for monomerid = 50057511
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C beta type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	174	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]- PDBu from Protein kinase C beta C1a domain				Bioorg Med Chem Lett 10: 2087-90 (2000) BindingDB Entry DOI: 10.7270/Q22F7NZS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C gamma type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from PKCgamma C1B domain				Bioorg Med Chem 16: 650-7 (2008) Article DOI: 10.1016/j.bmc.2007.10.045 BindingDB Entry DOI: 10.7270/Q2XS5W85
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C gamma type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	213	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]- PDBu from Protein kinase C gamma C1b domain				Bioorg Med Chem Lett 10: 2087-90 (2000) BindingDB Entry DOI: 10.7270/Q22F7NZS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C gamma type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	213	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C gamma C1a domain				Bioorg Med Chem Lett 11: 723-8 (2001) BindingDB Entry DOI: 10.7270/Q2QV3KRS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Mus musculus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	658	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (T8G)				J Med Chem 44: 1690-701 (2001) BindingDB Entry DOI: 10.7270/Q2RR1ZX3
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Mus musculus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	658	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Tyr8 to Gly)				J Med Chem 42: 3436-46 (1999) Article DOI: 10.1021/jm990129n BindingDB Entry DOI: 10.7270/Q25T3JP5
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Mus musculus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (Q27V)				J Med Chem 44: 1690-701 (2001) BindingDB Entry DOI: 10.7270/Q2RR1ZX3
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Mus musculus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Gln27 to Val)				J Med Chem 42: 3436-46 (1999) Article DOI: 10.1021/jm990129n BindingDB Entry DOI: 10.7270/Q25T3JP5
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Binding affinity for Protein kinase C alpha C1a domain				Bioorg Med Chem Lett 10: 2087-90 (2000) BindingDB Entry DOI: 10.7270/Q22F7NZS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C delta C1a domain				Bioorg Med Chem Lett 11: 723-8 (2001) BindingDB Entry DOI: 10.7270/Q2QV3KRS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C eta type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	3.77E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C eta C1a domain				Bioorg Med Chem Lett 11: 723-8 (2001) BindingDB Entry DOI: 10.7270/Q2QV3KRS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C eta type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	3.77E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]- PDBu from Protein kinase C eta C1a domain				Bioorg Med Chem Lett 10: 2087-90 (2000) BindingDB Entry DOI: 10.7270/Q22F7NZS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C beta type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from PKCbeta C1B domain				Bioorg Med Chem 16: 650-7 (2008) Article DOI: 10.1016/j.bmc.2007.10.045 BindingDB Entry DOI: 10.7270/Q2XS5W85
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from PKCalpha C1B domain				J Med Chem 51: 46-56 (2008) Article DOI: 10.1021/jm0706719 BindingDB Entry DOI: 10.7270/Q2445M7Q
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C alpha C1b domain				Bioorg Med Chem Lett 11: 723-8 (2001) BindingDB Entry DOI: 10.7270/Q2QV3KRS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]- PDBu from Protein kinase C alpha C1b domain				Bioorg Med Chem Lett 10: 2087-90 (2000) BindingDB Entry DOI: 10.7270/Q22F7NZS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C epsilon type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	4.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C beta C1b domain				Bioorg Med Chem Lett 11: 723-8 (2001) BindingDB Entry DOI: 10.7270/Q2QV3KRS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C epsilon type (Homo sapiens (Human))	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	4.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]- PDBu from Protein kinase C epsilon C1a domain				Bioorg Med Chem Lett 10: 2087-90 (2000) BindingDB Entry DOI: 10.7270/Q22F7NZS
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Mus musculus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Pro11 to Gly)				J Med Chem 42: 3436-46 (1999) Article DOI: 10.1021/jm990129n BindingDB Entry DOI: 10.7270/Q25T3JP5
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Mus musculus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	7.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]-PDBu from protein kinase C delta C1b domain mutant (P11G)				J Med Chem 44: 1690-701 (2001) BindingDB Entry DOI: 10.7270/Q2RR1ZX3
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C gamma type (Rattus norvegicus)	BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to rat brain protein kinase C gamma regulatory domain				Citation and Details BindingDB Entry DOI: 10.7270/Q2GM89G6
TBA					More data for this Ligand-Target Pair

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