null

SMILES: Clc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1

InChI Key: InChIKey=OHYMOQNKNZPCGJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50058052   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058052 (CHEMBL3330805 | US9260448, 7) Show SMILES Clc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI InChI=1S/C18H11ClN2OS/c19-13-6-8-14(9-7-13)21-11-20-16-15(10-23-17(16)18(21)22)12-4-2-1-3-5-12/h1-11H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058052 (CHEMBL3330805 | US9260448, 7) Show SMILES Clc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI InChI=1S/C18H11ClN2OS/c19-13-6-8-14(9-7-13)21-11-20-16-15(10-23-17(16)18(21)22)12-4-2-1-3-5-12/h1-11H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent					Assay Description Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...				US Patent US9260448 (2016) BindingDB Entry DOI: 10.7270/Q2H9941W
					More data for this Ligand-Target Pair