BDBM50059084 CHEMBL3393171::US10308663, Thienopyridone (5)

SMILES: Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1

InChI Key: InChIKey=FBVOPOZVLBHOHR-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50059084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein tyrosine phosphatase type IVA 1 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	173	n/a	n/a	n/a	n/a	n/a	n/a
European Molecular Biology Laboratory Curated by ChEMBL					Assay Description Inhibition of full length human fusion His6 tagged PRL1 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...				Eur J Med Chem 88: 89-100 (2014) Article DOI: 10.1016/j.ejmech.2014.08.060 BindingDB Entry DOI: 10.7270/Q2FQ9Z8G
					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	277	n/a	n/a	n/a	n/a	n/a	n/a
European Molecular Biology Laboratory Curated by ChEMBL					Assay Description Inhibition of human PRL2 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by immobilized metal ion affinity-bas...				Eur J Med Chem 88: 89-100 (2014) Article DOI: 10.1016/j.ejmech.2014.08.060 BindingDB Entry DOI: 10.7270/Q2FQ9Z8G
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 4A3 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
European Molecular Biology Laboratory Curated by ChEMBL					Assay Description Inhibition of full length human fusion His6 tagged PRL3 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...				Eur J Med Chem 88: 89-100 (2014) Article DOI: 10.1016/j.ejmech.2014.08.060 BindingDB Entry DOI: 10.7270/Q2FQ9Z8G
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 4A3 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
European Molecular Biology Laboratory Curated by ChEMBL					Assay Description Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation				Eur J Med Chem 88: 89-100 (2014) Article DOI: 10.1016/j.ejmech.2014.08.060 BindingDB Entry DOI: 10.7270/Q2FQ9Z8G
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 4A3 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048
					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
European Molecular Biology Laboratory Curated by ChEMBL					Assay Description Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation				Eur J Med Chem 88: 89-100 (2014) Article DOI: 10.1016/j.ejmech.2014.08.060 BindingDB Entry DOI: 10.7270/Q2FQ9Z8G
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 4A3 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....				Bioorg Med Chem Lett 17: 4664-9 (2007) BindingDB Entry DOI: 10.7270/Q20867N2
					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A2 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048
					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A1 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048
					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 | US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+5	n/a	n/a	n/a	n/a	n/a	n/a
European Molecular Biology Laboratory Curated by ChEMBL					Assay Description Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation				Eur J Med Chem 88: 89-100 (2014) Article DOI: 10.1016/j.ejmech.2014.08.060 BindingDB Entry DOI: 10.7270/Q2FQ9Z8G
					More data for this Ligand-Target Pair