BDBM50059961 2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-4-one::2-(3-chlorophenyl)-6-methyl-1,8-naphthyridin-4(1H)-one::CHEMBL49827::NSC-679036

SMILES: Cc1cnc2nc(cc(O)c2c1)-c1cccc(Cl)c1

InChI Key: InChIKey=FSWIIQLXZOJBSF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50059961   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tubulin (Sus scrofa (Pig))	BDBM50059961 (2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...) Show SMILES Cc1cnc2nc(cc(O)c2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H11ClN2O/c1-9-5-12-14(19)7-13(18-15(12)17-8-9)10-3-2-4-11(16)6-10/h2-8H,1H3,(H,17,18,19)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	724	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization interacting at the colchicine binding site.				J Med Chem 43: 167-76 (2000) BindingDB Entry DOI: 10.7270/Q2CV4JZB
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50059961 (2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...) Show SMILES Cc1cnc2nc(cc(O)c2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H11ClN2O/c1-9-5-12-14(19)7-13(18-15(12)17-8-9)10-3-2-4-11(16)6-10/h2-8H,1H3,(H,17,18,19)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Concentration inhibiting tubulin polymerization (ITP)				J Med Chem 42: 4081-7 (1999) Article DOI: 10.1021/jm990208z BindingDB Entry DOI: 10.7270/Q2Z60RSS
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50059961 (2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...) Show SMILES Cc1cnc2nc(cc(O)c2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H11ClN2O/c1-9-5-12-14(19)7-13(18-15(12)17-8-9)10-3-2-4-11(16)6-10/h2-8H,1H3,(H,17,18,19)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization				J Med Chem 40: 3049-56 (1997) Article DOI: 10.1021/jm970146h BindingDB Entry DOI: 10.7270/Q2TQ648T
					More data for this Ligand-Target Pair