BDBM50059964 6-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-one::6-methyl-2-(naphthalen-1-yl)-1,8-naphthyridin-4(1H)-one::CHEMBL50666

SMILES: Cc1cnc2nc(cc(O)c2c1)-c1cccc2ccccc12

InChI Key: InChIKey=KBQRHVUXLRZRAC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50059964   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50059964 (6-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-...) Show SMILES Cc1cnc2nc(cc(O)c2c1)-c1cccc2ccccc12 Show InChI InChI=1S/C19H14N2O/c1-12-9-16-18(22)10-17(21-19(16)20-11-12)15-8-4-6-13-5-2-3-7-14(13)15/h2-11H,1H3,(H,20,21,22)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization				J Med Chem 40: 3049-56 (1997) Article DOI: 10.1021/jm970146h BindingDB Entry DOI: 10.7270/Q2TQ648T
					More data for this Ligand-Target Pair
Tubulin (Sus scrofa (Pig))	BDBM50059964 (6-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-...) Show SMILES Cc1cnc2nc(cc(O)c2c1)-c1cccc2ccccc12 Show InChI InChI=1S/C19H14N2O/c1-12-9-16-18(22)10-17(21-19(16)20-11-12)15-8-4-6-13-5-2-3-7-14(13)15/h2-11H,1H3,(H,20,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization interacting at the colchicine binding site.				J Med Chem 43: 167-76 (2000) BindingDB Entry DOI: 10.7270/Q2CV4JZB
					More data for this Ligand-Target Pair