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BDBM50060148 CHEMBL325331::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-pentylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester

SMILES: CCCC(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1

InChI Key: InChIKey=HOBCNABKXVPKMF-SHXCFHCCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50060148   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ha-Ras-CVLS


(Homo sapiens (human))
BDBM50060148
PNG
(CHEMBL325331 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Show SMILES CCCC(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C41H45N5O5/c1-2-12-35(34-17-10-5-11-18-34)24-43-39(47)27-46(26-31-19-21-37(22-20-31)50-28-32-13-6-3-7-14-32)40(48)38(23-36-25-42-30-44-36)45-41(49)51-29-33-15-8-4-9-16-33/h3-11,13-22,25,30,35,38H,2,12,23-24,26-29H2,1H3,(H,42,44)(H,43,47)(H,45,49)/t35?,38-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .


J Med Chem 40: 3319-22 (1997)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50060148
PNG
(CHEMBL325331 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Show SMILES CCCC(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C41H45N5O5/c1-2-12-35(34-17-10-5-11-18-34)24-43-39(47)27-46(26-31-19-21-37(22-20-31)50-28-32-13-6-3-7-14-32)40(48)38(23-36-25-42-30-44-36)45-41(49)51-29-33-15-8-4-9-16-33/h3-11,13-22,25,30,35,38H,2,12,23-24,26-29H2,1H3,(H,42,44)(H,43,47)(H,45,49)/t35?,38-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
In vitro inhibition of rat farnesyltransferase.


J Med Chem 40: 3319-22 (1997)

More data for this
Ligand-Target Pair