BDBM50061314 8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline::8-methoxy-1,2,3,4-tetrahydrobenzo[h]isoquinoline::CHEMBL338311
SMILES: COc1ccc2c3CNCCc3ccc2c1
InChI Key: InChIKey=LTVUTAZPBISUIF-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenylethanolamine N-methyltransferase (Bos taurus (bovine)) | BDBM50061314 (8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibition of Phenylethanolamine N-methyltransferase (PNMT) | J Med Chem 40: 3997-4005 (1998) Article DOI: 10.1021/jm960235e BindingDB Entry DOI: 10.7270/Q2B27TDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50061314 (8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor | Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylethanolamine N-methyltransferase (Bos taurus (bovine)) | BDBM50061314 (8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 7.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) | Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9 | |||||||||||
More data for this Ligand-Target Pair |