BDBM50061489 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone::CHEMBL335685::SCH-44324

SMILES: Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1

InChI Key: InChIKey=IBAHDARYZDKLAE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50061489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50061489 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-7-8-23-21(16-22)6-5-20-4-2-12-29-26(20)25(23)19-9-13-30(14-10-19)24(31)15-18-3-1-11-28-17-18/h1-4,7-8,11-12,16-17H,5-6,9-10,13-15H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human farnesyltransferase				J Med Chem 40: 4103-12 (1998) Article DOI: 10.1021/jm970291v BindingDB Entry DOI: 10.7270/Q2T152R0
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50061489 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-7-8-23-21(16-22)6-5-20-4-2-12-29-26(20)25(23)19-9-13-30(14-10-19)24(31)15-18-3-1-11-28-17-18/h1-4,7-8,11-12,16-17H,5-6,9-10,13-15H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Farnesyltransferase				J Med Chem 40: 4290-301 (1998) Article DOI: 10.1021/jm970464g BindingDB Entry DOI: 10.7270/Q2NC60B2
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50061489 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-7-8-23-21(16-22)6-5-20-4-2-12-29-26(20)25(23)19-9-13-30(14-10-19)24(31)15-18-3-1-11-28-17-18/h1-4,7-8,11-12,16-17H,5-6,9-10,13-15H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Geranylgeranyl transferase type I				J Med Chem 40: 4290-301 (1998) Article DOI: 10.1021/jm970464g BindingDB Entry DOI: 10.7270/Q2NC60B2
					More data for this Ligand-Target Pair