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SMILES: Oc1ccc2CC[C@H](CNCc3ccccc3)Oc2c1
InChI Key: InChIKey=DWUAAOIZQFTYQP-MRXNPFEDSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon... | Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity to rat striatal Dopamine receptor D2 was determined using the antagonist [3H]spiperone + GTP to label the low affinity stat... | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranes | J Med Chem 42: 2007-20 (1999) Article DOI: 10.1021/jm990023s BindingDB Entry DOI: 10.7270/Q25D8R1W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranes | J Med Chem 42: 2007-20 (1999) Article DOI: 10.1021/jm990023s BindingDB Entry DOI: 10.7270/Q25D8R1W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenates | J Med Chem 42: 2007-20 (1999) Article DOI: 10.1021/jm990023s BindingDB Entry DOI: 10.7270/Q25D8R1W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperone | Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperone | Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperone | Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity to rat hippocampal 5-hydroxytryptamine 1A receptor was determined using [3H]8-OH-DPAT as radioligand | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity at human Dopamine receptor D4 (hD4) using [3H]spiperone radioligand. | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity to rat striatal Dopamine receptor D2 was determined using the agonist [3H]quinpirole to label the high affinity state (D2 h... | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity at human Dopamine receptor D3 (hD3) using [3H]spiperone radioligand. | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity at human Dopamine receptor D2 (hD2) using [3H]spiperone radioligand. | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells | J Med Chem 46: 4377-92 (2003) Article DOI: 10.1021/jm030085p BindingDB Entry DOI: 10.7270/Q21V5FPS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 736 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from low-affinity state of human dopamine D2S receptor transfected in HEK293 cells after 2 hrs by scintillation countin... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from low-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation countin... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from high-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation counti... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 736 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from low-affinity state of human dopamine D2S receptor transfected in HEK293 cells after 2 hrs by scintillation countin... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 70.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from low-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation countin... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from high-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation counti... | J Med Chem 57: 391-410 (2014) Article DOI: 10.1021/jm401384w BindingDB Entry DOI: 10.7270/Q2WS8VQD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50061669 ((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga... | Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
