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BDBM50061815 8-Chloro-11-[1-(2-pyridin-4-yl-acetyl)-piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-3-carbonitrile::CHEMBL335730

SMILES: Clc1ccc2c(-[#6]-[#6]-c3cc(cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)C#N)c1

InChI Key: InChIKey=AMUVTFDBOFEYBQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50061815   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))		BDBM50061815
PNG
(8-Chloro-11-[1-(2-pyridin-4-yl-acetyl)-piperidin-4...)
Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)C#N)c1
Show InChI InChI=1S/C27H23ClN4O/c28-23-3-4-24-21(15-23)1-2-22-13-19(16-29)17-31-27(22)26(24)20-7-11-32(12-8-20)25(33)14-18-5-9-30-10-6-18/h3-6,9-10,13,15,17H,1-2,7-8,11-12,14H2
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Farnesyltransferase

J Med Chem 40: 4290-301 (1998)


Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2
More data for this
Ligand-Target Pair