BDBM50062249 CHEMBL285434::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5R)-1,3-dioxolane-2,2,4-tricarboxylate
SMILES: C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O
InChI Key: InChIKey=CXDSZFRIMJUZKT-OBCHTKLQSA-K
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50062249 (CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inhibition of Farnesyltransferase in competitive manner with respect to FPP (farnesyl diphosphate) at 0.6 microM FPP and 0.36 microM Ras peptide | J Med Chem 41: 143-7 (1998) Article DOI: 10.1021/jm970540f BindingDB Entry DOI: 10.7270/Q23B5Z82 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50062249 (CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inhibition of Farnesyltransferase in competitive manner with respect to FPP (farnesyl diphosphate) at 0.6 microM FPP and 3.6 microM Ras peptide. | J Med Chem 41: 143-7 (1998) Article DOI: 10.1021/jm970540f BindingDB Entry DOI: 10.7270/Q23B5Z82 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50062249 (CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inhibition of FTase in competitive manner with respect to FPP (farnesyl diphosphate) at 6.0 microM FPP and 0.36 microM Ras peptide. | J Med Chem 41: 143-7 (1998) Article DOI: 10.1021/jm970540f BindingDB Entry DOI: 10.7270/Q23B5Z82 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50062249 (CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inhibition of Farnesyltransferase from rat brain | J Med Chem 41: 143-7 (1998) Article DOI: 10.1021/jm970540f BindingDB Entry DOI: 10.7270/Q23B5Z82 | |||||||||||
More data for this Ligand-Target Pair |