BindingDB PrimarySearch

BDBM50063137 (R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-butyric acid::CHEMBL160153

SMILES: CSc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O

InChI Key: InChIKey=CTGTUEAFFDISNJ-QGZVFWFLSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50063137
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-1				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-7				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Neutral Endopeptidase (NEP) (Rattus norvegicus (Rat))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against neutral endopeptidase (NEP)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-3				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin-converting enzyme (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Angiotensin I converting enzyme				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against endothelin converting enzyme (ECE)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
Shionogi & Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair